Whey Protein, Colostrum, Glutathione, Selenium, Weight Loss, Diet, Immunity and more: What the Experts Say
What follows are quotes from credentialed experts on Whey Protein, Colostrum, Glutathione, Selenium, Weight Loss, Diet, Immunity and more from reputable sources. These are provided as a quick review of the scientific support for the mentioned foods and nutraceuticals as reasonable ingredients for inclusion in designing a zoonutrient dense functional food. These quotes should NOT be taken as disease treatment, cure, or prevention claims for any BioPharma product.
"Understanding how molecular structures have evolved to provide nutritional functions in animals will lead to a new generation of foods that can deliver on the promise of maintaining optimal health (in humans)." -Robert E. Ward And J. Bruce, Zoonutrients and Health, Food Technology, Vol 57, March 03, pp 30- 36
"Development of high-protein low-carbohydrate beverages might provide health benefits for individuals suffering from diabetes, obesity, and hypercholesterol-emia, especially when these beverages contain dairy protein fractions known to be high in essential amino acids and branched-chain amino acids." - Etzel, M.R., Manufacture and use of dairy protein fractions., J Nutr. 2004 Apr;134(4):996S-1002S.
"The proteins...of whey...belong to the proteins with the highest biological value because of their amino acid composition...Biological active peptide sequences which become effective during digestion...are of importance for secretion of entero-hormones as well as for immune enhancing effects." Barth CA, Behnke U., Nutritional physiology of whey and whey components, Nahrung. 1997 Feb;41(1):2-12.
"Non-denatured pharmaceutical grade whey proteinØy«contain(s) cystine rich proteins such as alpha-lactalbumin, serum albumin, and lactoferrin. Cystine (double bonded cysteine) easily traverses the gut and passes into the cell where it isØy«then available for glutathione production. Whey protein isolate formulas (Øy«non-denatured) have been clinically proven to raise intracellular glutathione levels." Bounous, G., and P. Gold. 1991. The biological activity of undenatured whey proteins: role of glutathione. Clin. Invest Med.; 14:296Øy«309.
"Whey based peptides?may reduce both hypertension and dyslipidemia ? bioactive whey peptides may be involved in ? ACE inhibitory activity, antioxidant activity, anti-thrombotic activity, cholesterol-reducing activity." Sharon K. Gerdes, W. James Harper, Ph.D., G. Miller, Ph.D.; ?Bioactive Components of Whey and Cardio-vascular Health?, Applications Monograph, Cardiovascular Health
"Whey proteins and amino acid supplements have a strong position in the sports nutrition market... Recent studies...demonstrate the ability of whey proteins...to promote whole body and muscle protein synthesis...Many bioactive components derived from whey are under study for their... capacity...to modulate adiposity, and to enhance immune function and anti-oxidant activity? Whey proteins...may be able to provide substrate and bioactive components to extend the overall benefits of physical activity." Ha E, Zemel MB, Functional properties of whey, whey components, and essential amino acids: mechanisms underlying health benefits for active people, Functional Ingredients Research, Inc, Twin Falls, Idaho, USA.
"? on neoplastic development?individual milk fats like conjugated linoleic acid and glycol-shingolipids could exert inhibitory effects? bovine lactoferrin inhibits colon carcinogenesis?without any overt toxicity?bovine lactoferrin might find application? for chemoprevention of colon and other cancers." - Tsuda H, Sekine K., Milk Components as Cancer Chemopreventive Agents.,Asian Pac J Cancer Prev. 2000;1(4):277-282.
"Cysteine is the rate-limiting amino acid for synthesis of the ubiquitous antioxidant glutathione (GSH). Bovine whey proteins are rich in cystine, the disulfide form of the amino acid cysteine... The results of this study indicate that WPI can increase GSH synthesis and protect against oxidant-induced cell death in human prostate cells." Kent KD, Harper WJ, Bomser JA., Effect of whey protein isolate on intracellular glutathione and oxidant-induced cell death in human prostate epithelial cells, Toxicol In Vitro. 2003 Feb;17(1):27-33.
"Epidemiological and experimental studies suggest that? dietary milk products may exert an inhibitory effect on the development of several types of tumors... whey protein diets result in increased glutathione (GSH) concentration in a number of tissues, and that some of the beneficial effects of whey protein intake are abrogated by inhibition of GSH synthesis. Whey protein is particularly rich in substrates for GSH synthesis. We suggest that whey protein may be exerting its effect on carcinogenesis by enhancing GSH concentration." Bounous G, Batist G, Gold P. Whey proteins in cancer prevention. Cancer Lett. 1991 May 1;57(2):91-4.
"HIV infection is characterized by an enhanced oxidant burden and a systemic deficiency of the tripeptide glutathione (GSH), a major antioxidant. The semi-essential amino acid cysteine is the main source of the free sulfhydryl group of GSH and limits its synthesis... Whey proteins are rich in cysteine as well as in GSH precursor peptides. Supplementation with whey proteins persistently increased plasma glutathione levels in patients with advanced HIV-infection." Micke P, Beeh KM, Buhl R., Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients, Eur J Nutr. 2002 Feb;41(1):12-8.
"Even after controlling for known confounders including weight loss, women and men with relatively lower protein intake had increased bone loss, suggesting that protein intake is important in maintaining bone or minimizing bone loss in elderly persons." Hannan, M.T., Tucker, K.L., Dawson-Hughes, B., et al., "Effect of Dietary Protein on Bone Loss in Elderly Men and Women: The Framingham Osteoporosis Study," Journal of Bone Mineral Research, 15(12), 2000, pages 2504-2512
"More desirable milk protein compositionØy«is obtained by the addition of lactoferrin and Øy«sub-fractionsØy«Optimization of heating processes is important to minimize the destruction of milk components during fractionation and preservation processes." - de Wit JN, Marschall Rhone-Poulenc Award Lecture. Nutritional and functional characteristics of whey proteins in food products, Centre for Protein Technology Wageningen Agricultural University, The Netherlands.
"Bovine colostrums ? nutrient profile (includes)?immunoglobulins, growth factors, cytokines, and nucleosides?oligosaccharides, antimicrobials, and immune-regulating factors? evidence suggests a beneficial effect ?in improving body composition,? athletic performance, diarrhea?, NSAID-induced gastrointestinal disturbances, ? (and) in conditions associated with these infectious organisms. " - Kelly GS., Bovine colostrums: a review of clinical uses Altern Med Rev. 2003 Nov;8(4):378-94.
"Colostrum contains cytokines and other protein compounds (immune complexes) of very low molecular weight that can act as Biological Response Modifiers (BMRs), which intervene locally in most biological processes."-Alejandro Nitsch, M.D.; Fabiola P. Nitsch, M.D. The Clinical Use of Bovine Colostrum , The Journal of Orthomolecular Medicine, Second Quarter 1998 - Volume 13, Number 2
"Colostrum has been demonstrated to enhance athletic performance and increase lean body mass in humans."Journal Sports Sciences 2003 21:577-88, (Mero et. al. (1997) J. Appl. Physiol. 83: 1144 ? 1151; Buckley, J. D. et. al. (2000) Asian Aust. J. Anim. Sci. 13: 312 ? 315; Sanders, A. J. and Van Gammeren, D. (2000) Nutrition 3: 343 ? 347
"Colostrum also reduces the detrimental effects attributable to microbial infection, decreases fat metabolism in old animals, reduces allergies and autoimmune diseases, heart disease, athletic stress, leaky gut syndrome, cancer, diabetes, and increases wound healing"-Reviewed in Rona, Z. P. (1998) Am. J. Natural Med.
"Colostrum improves liver function by reducing the effects of toxic metabolites on the liver and provides desirable protein-rich nutrition for people suffering from a variety of liver disorders.Øy« -U.S. Pat. No. 5, 710, 132, 1996, Use of bovine colostral milk as a preparation for the protection of the liver.
"Growth and Immune Factors isolated from colostrum, Øy«accelerate healing, balance blood sugar, reduce insulin need, and increase muscle and bone growth, while reducing fat.Øy« Reviewed in Pakkanen R. and Alto J. (1997) Int. Dairy J.: 285 Øy« 297
"PRP (proline rich polypeptides) activates an underactive immune system, helping it move into action against disease-causing organisms. PRP also suppresses an overactive immune system, such as is often seen in the autoimmune diseases. PRP is highly anti-inflammatory and also appears to act on T-cell precursors to produce helper T-cells and suppresser T-cells" Staroscik, et. al., "Immunologically active nonapeptide fragment of a proline-rich polypeptide from ovine colostrum: amino acid sequence and immunoregulatory properties". Mol Immunol. 1983 Dec;20(12):1277-82.
"PRP turns white blood cells into functionally active T cells. Results were shown in treatment of auto-immune disorders and cancer. An important Immune modulator stimulates an underactive immune system and tones down an overactive one"- M Zimecki, M Janusz, K Staroscik, J Lisowski, and Z Wieczorek, Effect of proline-rich polypeptide on donor cells in graft-versus-host reaction. Immunology. 1982 September; 47(1): 141Øy«147.
"Glutathione has antioxidant,...detoxification, and immuno-modulatory activitiesØy«" PDR Health, http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/glu_0126.shtml
Glutathione has been called the master antioxidant because of its critical roles in metabolic mechanisms and pathways. Uniquely, this simple tripeptide is ubiquitous and found in virtually all animal, plant, and microbial cells. Calvin A. Lang. Journal of Anti-Aging Medicine. 2001, 4(2): 137-144. doi:10.1089/10945450152466189.
"Selenium has antioxidant activity. Selenium may also have immunomodulatory, anti-carcinogenic and anti-atherogenic activities. It may have activity in detoxification of some metals and other xenobiotics and activity in fertility enhancement in males." PDR Health http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/sel_0232.shtml
"Inulins prebiotic soluble fibers, Øy«may have anti-tumor, anti-microbial, hypo-lipidemic and hypoglycemic actions. They may also help to improve mineral absorption and balance and may have anti-osteoporotic activity."- PDR Health http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/inu_0299.shtml